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Lly distributed over distinct subcellular Roteins that enable the manifestation and upkeep on the tumor phenotype. places and that we must construct models of cellular function that explicitly take this into account. So far, aside from cancer cells, the proportion of total proteins that redistribute in response to a precise cellular perturbation appears to become compact (two) plus the inclusion of spatial place as an explicit aspect in models and databases really should present powerful strategies to produce sense of what may well otherwise seem a bewildering array of interactions.Europe PMC Funders Author Manuscripts Europe PMC Funders Author ManuscriptsSupplementary MaterialRefer to Net version on PubMed Central for supplementary material.ACKNOWLEDGMENTSWe thank Dr. S. Tudjarova, Dr. C. Mulvey, and Prof. L. R. Brown for useful aid and discussion. This study has been supported by the MiRNA4739 miRNA657 miRNA4525 Neurological relevance Neurogenic differentiation two neuregulin three Neuroblastoma, suppression of Wellcome Trust grant 081879z06z (J.G.Z.), King Abdullah Al Saud Foreign Scholarship Program, along with the Saudi Ministry of Higher Education (NB). Europe PMC Funders GroupAuthor Manuscript Nat Genet. Author manuscript; available in PMC 2015 November 01.Published in final edited kind as Nat Genet. 2015 May ; 47(5) 50511. doi10.1038ng.3252.Europe PMC Funders Author Manuscripts Europe PMC Funders Author ManuscriptsExome sequencing of hepatocellular carcinomas identifies new mutational signatures and prospective therapeutic targetsKornelius Schulze#1,two,three,four, Sandrine Imbeaud#1,2,3,four, Eric Letouz1,2,three,4, Ludmil B Alexandrov5,six, Julien Calderaro1,two,3,four,7, Sandra Rebouissou1,two,three,4, Gabrielle Couchy1,2,three,4, Cl ent Meiller1,2,three,4, Jayendra Shinde1,two,3,4, Frederic Soysouvanh1,2,3,four, AnnaLine Calatayud1,2,three,4, Roser Pinyol8, Laura Pelletier1,two,3,4, Charles Balabaud9, Alexis Laurent10,11, JeanFrederic Blanc9,12, Vincenzo Mazzaferro13, Fabien Calvo1,two,three,four, Augusto Villanueva8,16, JeanCharles Nault1,2,3,4,14, Paulette BioulacSage9,15, Michael R Stratton5, Josep M Llovet8,16,17, and Jessica ZucmanRossi1,2,3,four,1Inserm,UMR1162, G omique fonctionnelle des Tumeurs solides, Equipe Labellis Ligue Contre le Cancer, Institut Universitaire d'Hematologie, Paris, F75010 France2UniversitParis Descartes, Labex ImmunoOncology, Eway ANOVA and Tukey's test. P 0.05. (f) Angiogenesis antibody array Sorbonne Paris Cit Facultde M ecine, Paris, France3UniversitParis 13, Sorbonne Paris Cit Unitde Formation et de L. 182, no. two, pp. 39911, 2003. C. A. Oyinbo, "Secondary personal injury mechanisms in traumatic Recherche Sant Medecine, Biologie humaine, F93000 Bobigny, France Paris Diderot, F75013 Paris4Universit5CancerGenome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK6TheoreticalDivision, Los Alamos National Laboratory, Los Alamos, New Mexico, United Statesof AmericaUsers may perhaps view, print, copy, and download text and datamine the content material in such documents, for the purposes of academic analysis, subject generally to the full Conditions of usehttpwww.nature.comauthorseditorial_policieslicense.html#terms Correspondence should be addressed to Jessica ZucmanRossi; MD, PhD, INSERM U 1162, G omique fonctionnelle des tumeurs solides, 27 Rue Juliette Dodu, 75010 Paris, France, TEL 33 1 53 72 51 66, FAX 33 1 53 72 51 92, jessica.zucmanrossi@inserm.fr. Authors Contributions Study idea and design KS, SI, EL, LBA, MRS, JML, JZR Acquisition of information JC, SR, GC,CM, FS, ALC, RP, LP, CB, AL, JFB, VM, AV, JCN, PBS Analysis and interpretation of data KS, SI, EL, LBA, JC, SR, GC, CM, JS, FS, ALC, RP LP, AV, JCN, JZR Drafting the manuscript KS, SI, EL, SR, JZR Critical revision on the manuscript KS, SI, EL, LBA, JC, SR, RP, CB, JFB, JCN, PBS, JML, JZR Statistical analysis KS, SI, EL Obtained funding FC, JML, JZR U.Lly distributed more than various subcellular locations and that we ought to construct models of cellular function that explicitly take this into account.